Abstract:
Recent developments in optogenetics have demonstrated that modulating the targeted neurons and projections in the brain is capable of rescuing behavioral deficits associated with depression, autism, anxiety, and epilepsy. However, due to limited tissue penetration of visible light, invasive craniotomy and intracranial implantation of optical fibers are generally required. In this presentation, I will discuss nanoparticle-based approaches to address the challenge, particularly the application of organic nanoparticles to be activated by brain-penetrant focused ultrasound for non-invasive genetically-targeted neuromodulation.
In addition, current implanted electronics could be used for long-term neuromodulation and neurorecording but requires invasive surgery for implantations. Non-invasive neuromodulation and neurorecording methods, on the other hand, could not be applied over time. In the second part of the presentation. I will discuss the strategies to fabricate wearable ultrasound stimulation and electrical recording electronics to achieve non-invasive and long-term neuromodulation and neurorecording, including the fabrication of miniaturized electronics and the development of long-term stable hydrogels for these applications.
To join virtually:
https://iu.zoom.us/j/87661619145