Abstract:
Traditional approaches for determining the impact of prenatal cannabis exposure has rested on the notion that THC or CBD disrupt endogenous endocannabinoid signaling via the canonical CB1 and CB2 or other GPCR receptors. Considerable evidence supports this framework, including our own work using a model of gestational exposure to THC and effects on the developing brain. We find the timing of THC exposure impacts the developmental outcome, suggesting disruption of the endocannabinoid system during particular epochs or sensitive periods differentially impacts brain development. In addition to the disruption of the endocannabinoid system, we now find a simultaneous, and presumably in parallel, process involves THC binding to nuclear steroid receptors, in particular androgen and progesterone receptors. A combination of in silico and in vivo biochemical assays combined with in vivo cellular and behavioral endpoints support the
notion that THC actions are multifactorial. This seminar will explore the impact of
developmental THC exposure on adolescent social behaviors and the cellular and
molecular endpoints mediating those effects in the laboratory rat. An overarching goal is to illuminate the potential risks of cannabis use during pregnancy while also highlighting potential benefits and drug discovery potential.